Melding synthetic molecules and genetically encoded proteins to forge new tools for neuroscience

Publication
Annual Review of Neuroscience, 45(xx), XX-XXX

Abstract

Unraveling the complexity of the brain requires sophisticated methods to probe and perturb neurobiological processes with high spatiotemporal control. The field of chemical biology has produced general strategies to combine the molecular specificity of small-molecule tools with the cellular specificity of genetically encoded reagents. Here, we survey the application, refinement, and extension of these hybrid small-molecule:protein methods to problems in neuroscience, which yields powerful reagents to precisely measure and manipulate neural systems.

Pratik Kumar, PhD
Pratik Kumar, PhD
HHMI Postdoctoral Associate

I am a chemical biologist and I make chemical tools for biology.

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