Bioorthogonal Neurotransmitter

Stable Cyclopropene-Containing Analogs of the Amino Acid Neurotransmitter Glutamate

As a neurotransmitter, the amino acid glutamate has been the subject of efforts to generate structural analogs with unique properties. Here we report a practical, half-gram synthesis of two cyclopropene-containing glutamate analogs. These analogs are …

Bioorthogonal Neurotransmitters

Bringing bioorthogonal chemistry to the realm of neuroscience

A Photocaged, Cyclopropene-Containing Analog of the Amino Acid Neurotransmitter Glutamate

Substituted cyclopropenes serve as compact biorthogonal appendages that enable analysis of biomolecules in complex systems. Neurotransmitters, a chemically diverse group of biomolecules that control neuron excitation and inhibition, are not among the …