Lipidated Cyclopropenes via a Stable 3-N Spirocyclopropene Scaffold

Lipidated cyclopropenes serve as useful bioorthogonal reagents for imaging cell membranes due to the cyclopropene's small size and ability to ligate with pro-fluorescent tetrazines. Previously, the lipidation of cyclopropenes required modification at …

Inexpensive Multigram-Scale Synthesis of Cyclic Enamines and 3-*N* Spirocyclopropyl Systems

Cyclic enamines are important synthons for many synthetic and pharmacological targets. Here, we report an inexpensive, catalyst-free, multigram-scale synthesis for cyclic enamines with exocyclic double bonds and four- to seven-membered rings. This …

Lipidated Spirocyclopropyls

Synthesis of spirocyclic systems, cyclic enamines, and their conjugation to lipids